Enriched Expression of Neutral Sphingomyelinase 2 in the Striatum is Essential for Regulation of Lipid Raft Content and Motor Coordination

• Main Authors: Tan, L.H.-R, Tan, A.J.-R, Ng, Y.-Y, Chua, J.J.-E, Chew, W.-S, Muralidharan, S, Torta, F, Dutta, B, Sze, S.K, Herr, D.R, Ong, W.-Y
• Other Authors: PHYSIOLOGY
• Format: Article
• Published: Humana Press Inc. 2020
• Subjects: messenger RNA; neutral sphingomyelinase 2; sphingomyelin phosphodiesterase; unclassified drug; isoenzyme; proteome; sphingolipid; adult; animal cell; animal experiment; animal tissue; antibody labeling; Article; brain cortex; brain stem; cerebellum; controlled study; corpus striatum; dendritic spine; dorsal striatum; down regulation; electron microscopy; enzyme activity; enzyme inhibition; gene expression; glutamatergic synapse; hippocampus; lipid analysis; lipid metabolism; lipid raft; lipidomics; male; motor coordination; nerve ending; nonhuman; olfactory bulb; prefrontal cortex; protein expression; proteomics; quantitative analysis; rat; rotarod test; thalamus; acoustic reflex; animal; cytology; enzymology; gene expression regulation; gene knockdown; genetics; membrane microdomain; metabolism; motor activity; prepulse inhibition; startle reflex; ultrastructure; Wistar rat; Animals; Corpus Striatum; Gene Expression Regulation, Enzymologic; Gene Knockdown Techniques; Isoenzymes; Male; Membrane Microdomains; Motor Activity; Prepulse Inhibition; Proteome; Rats, Wistar; Reflex, Acoustic; Reflex, Startle; RNA, Messenger; Rotarod Performance Test; Sphingolipids; Sphingomyelin Phosphodiesterase
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/175111
• Institution: National University of Singapore

10.1007/s12035-017-0784-z