Enriched Expression of Neutral Sphingomyelinase 2 in the Striatum is Essential for Regulation of Lipid Raft Content and Motor Coordination

10.1007/s12035-017-0784-z

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Main Authors:	Tan, L.H.-R, Tan, A.J.-R, Ng, Y.-Y, Chua, J.J.-E, Chew, W.-S, Muralidharan, S, Torta, F, Dutta, B, Sze, S.K, Herr, D.R, Ong, W.-Y
Other Authors:	PHYSIOLOGY
Format:	Article
Published:	Humana Press Inc. 2020
Subjects:	messenger RNA neutral sphingomyelinase 2 sphingomyelin phosphodiesterase unclassified drug isoenzyme proteome sphingolipid adult animal cell animal experiment animal tissue antibody labeling Article brain cortex brain stem cerebellum controlled study corpus striatum dendritic spine dorsal striatum down regulation electron microscopy enzyme activity enzyme inhibition gene expression glutamatergic synapse hippocampus lipid analysis lipid metabolism lipid raft lipidomics male motor coordination nerve ending nonhuman olfactory bulb prefrontal cortex protein expression proteomics quantitative analysis rat rotarod test thalamus acoustic reflex animal cytology enzymology gene expression regulation gene knockdown genetics membrane microdomain metabolism motor activity prepulse inhibition startle reflex ultrastructure Wistar rat Animals Corpus Striatum Gene Expression Regulation, Enzymologic Gene Knockdown Techniques Isoenzymes Male Membrane Microdomains Motor Activity Prepulse Inhibition Proteome Rats, Wistar Reflex, Acoustic Reflex, Startle RNA, Messenger Rotarod Performance Test Sphingolipids Sphingomyelin Phosphodiesterase
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/175111
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Institution:	National University of Singapore

id	sg-nus-scholar.10635-175111
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spelling	sg-nus-scholar.10635-1751112024-05-08T09:50:53Z Enriched Expression of Neutral Sphingomyelinase 2 in the Striatum is Essential for Regulation of Lipid Raft Content and Motor Coordination Tan, L.H.-R Tan, A.J.-R Ng, Y.-Y Chua, J.J.-E Chew, W.-S Muralidharan, S Torta, F Dutta, B Sze, S.K Herr, D.R Ong, W.-Y PHYSIOLOGY PHARMACOLOGY MEDICINE BIOCHEMISTRY ANATOMY messenger RNA neutral sphingomyelinase 2 sphingomyelin phosphodiesterase unclassified drug isoenzyme messenger RNA proteome sphingolipid sphingomyelin phosphodiesterase adult animal cell animal experiment animal tissue antibody labeling Article brain cortex brain stem cerebellum controlled study corpus striatum dendritic spine dorsal striatum down regulation electron microscopy enzyme activity enzyme inhibition gene expression glutamatergic synapse hippocampus lipid analysis lipid metabolism lipid raft lipidomics male motor coordination nerve ending nonhuman olfactory bulb prefrontal cortex protein expression proteomics quantitative analysis rat rotarod test thalamus acoustic reflex animal corpus striatum cytology enzymology gene expression regulation gene knockdown genetics membrane microdomain metabolism motor activity prepulse inhibition startle reflex ultrastructure Wistar rat Animals Corpus Striatum Gene Expression Regulation, Enzymologic Gene Knockdown Techniques Isoenzymes Male Membrane Microdomains Motor Activity Prepulse Inhibition Proteome Rats, Wistar Reflex, Acoustic Reflex, Startle RNA, Messenger Rotarod Performance Test Sphingolipids Sphingomyelin Phosphodiesterase 10.1007/s12035-017-0784-z Molecular Neurobiology 55 7 5741-5756 2020-09-09T03:46:35Z 2020-09-09T03:46:35Z 2018 Article Tan, L.H.-R, Tan, A.J.-R, Ng, Y.-Y, Chua, J.J.-E, Chew, W.-S, Muralidharan, S, Torta, F, Dutta, B, Sze, S.K, Herr, D.R, Ong, W.-Y (2018). Enriched Expression of Neutral Sphingomyelinase 2 in the Striatum is Essential for Regulation of Lipid Raft Content and Motor Coordination. Molecular Neurobiology 55 (7) : 5741-5756. ScholarBank@NUS Repository. https://doi.org/10.1007/s12035-017-0784-z 0893-7648 https://scholarbank.nus.edu.sg/handle/10635/175111 Humana Press Inc. Unpaywall 20200831
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	messenger RNA neutral sphingomyelinase 2 sphingomyelin phosphodiesterase unclassified drug isoenzyme messenger RNA proteome sphingolipid sphingomyelin phosphodiesterase adult animal cell animal experiment animal tissue antibody labeling Article brain cortex brain stem cerebellum controlled study corpus striatum dendritic spine dorsal striatum down regulation electron microscopy enzyme activity enzyme inhibition gene expression glutamatergic synapse hippocampus lipid analysis lipid metabolism lipid raft lipidomics male motor coordination nerve ending nonhuman olfactory bulb prefrontal cortex protein expression proteomics quantitative analysis rat rotarod test thalamus acoustic reflex animal corpus striatum cytology enzymology gene expression regulation gene knockdown genetics membrane microdomain metabolism motor activity prepulse inhibition startle reflex ultrastructure Wistar rat Animals Corpus Striatum Gene Expression Regulation, Enzymologic Gene Knockdown Techniques Isoenzymes Male Membrane Microdomains Motor Activity Prepulse Inhibition Proteome Rats, Wistar Reflex, Acoustic Reflex, Startle RNA, Messenger Rotarod Performance Test Sphingolipids Sphingomyelin Phosphodiesterase
spellingShingle	messenger RNA neutral sphingomyelinase 2 sphingomyelin phosphodiesterase unclassified drug isoenzyme messenger RNA proteome sphingolipid sphingomyelin phosphodiesterase adult animal cell animal experiment animal tissue antibody labeling Article brain cortex brain stem cerebellum controlled study corpus striatum dendritic spine dorsal striatum down regulation electron microscopy enzyme activity enzyme inhibition gene expression glutamatergic synapse hippocampus lipid analysis lipid metabolism lipid raft lipidomics male motor coordination nerve ending nonhuman olfactory bulb prefrontal cortex protein expression proteomics quantitative analysis rat rotarod test thalamus acoustic reflex animal corpus striatum cytology enzymology gene expression regulation gene knockdown genetics membrane microdomain metabolism motor activity prepulse inhibition startle reflex ultrastructure Wistar rat Animals Corpus Striatum Gene Expression Regulation, Enzymologic Gene Knockdown Techniques Isoenzymes Male Membrane Microdomains Motor Activity Prepulse Inhibition Proteome Rats, Wistar Reflex, Acoustic Reflex, Startle RNA, Messenger Rotarod Performance Test Sphingolipids Sphingomyelin Phosphodiesterase Tan, L.H.-R Tan, A.J.-R Ng, Y.-Y Chua, J.J.-E Chew, W.-S Muralidharan, S Torta, F Dutta, B Sze, S.K Herr, D.R Ong, W.-Y Enriched Expression of Neutral Sphingomyelinase 2 in the Striatum is Essential for Regulation of Lipid Raft Content and Motor Coordination
description	10.1007/s12035-017-0784-z
author2	PHYSIOLOGY
author_facet	PHYSIOLOGY Tan, L.H.-R Tan, A.J.-R Ng, Y.-Y Chua, J.J.-E Chew, W.-S Muralidharan, S Torta, F Dutta, B Sze, S.K Herr, D.R Ong, W.-Y
format	Article
author	Tan, L.H.-R Tan, A.J.-R Ng, Y.-Y Chua, J.J.-E Chew, W.-S Muralidharan, S Torta, F Dutta, B Sze, S.K Herr, D.R Ong, W.-Y
author_sort	Tan, L.H.-R
title	Enriched Expression of Neutral Sphingomyelinase 2 in the Striatum is Essential for Regulation of Lipid Raft Content and Motor Coordination
title_short	Enriched Expression of Neutral Sphingomyelinase 2 in the Striatum is Essential for Regulation of Lipid Raft Content and Motor Coordination
title_full	Enriched Expression of Neutral Sphingomyelinase 2 in the Striatum is Essential for Regulation of Lipid Raft Content and Motor Coordination
title_fullStr	Enriched Expression of Neutral Sphingomyelinase 2 in the Striatum is Essential for Regulation of Lipid Raft Content and Motor Coordination
title_full_unstemmed	Enriched Expression of Neutral Sphingomyelinase 2 in the Striatum is Essential for Regulation of Lipid Raft Content and Motor Coordination
title_sort	enriched expression of neutral sphingomyelinase 2 in the striatum is essential for regulation of lipid raft content and motor coordination
publisher	Humana Press Inc.
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/175111
_version_	1800914342354354176

Enriched Expression of Neutral Sphingomyelinase 2 in the Striatum is Essential for Regulation of Lipid Raft Content and Motor Coordination

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