Major G‑quadruplex form of HIV‑1 LTR reveals a (3+1) folding topology containing a stem-loop

• Main Authors: Butovskaya, Elena, Heddi, Brahim, Bakalar, Blaž, Richter, Sara N., Phan, Anh Tuân
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Biological sciences; Genetics; G-quadruplex
• Online Access: https://hdl.handle.net/10356/139296
• Institution: Nanyang Technological University

Nucleic acids can form noncanonical four-stranded structures called G-quadruplexes. G-quadruplex-forming sequences are found in several genomes including human and viruses. Previous studies showed that the G-rich sequence located in the U3 promoter region of the HIV-1 long terminal repeat (LTR) fold...