Targeting Cx26 expression by sustained release of Cx26 antisense from scaffolds reduces inflammation and improves wound healing

• Main Authors: Phillips, Anthony R.J., Chin, Jiah Shin, Madden, Leigh, Gilmartin, Daniel J., Soon, Allyson, Thrasivoulou, Christopher, Jayasinghe, Suwan N., Miles, Michelle, O'Neill, Shay, Hu, Rebecca, Chew, Sing Yian, Becker, David Lawrence
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Medicine; Antisense Delivery; Cx26
• Online Access: https://hdl.handle.net/10356/139326
• Institution: Nanyang Technological University

The gap junction protein connexin 26 (Cx26) is expressed at high levels in naturally hyperthickened epidermal layers as well as pathological hyperkeratotic disease states, such as warts, psoriatic plaques, and chronic wound edges. The overexpression of Cx26 is also linked with inflammation, breakdow...