Sustained Release of Cx43 Antisense Oligodeoxynucleotides from Coated Collagen Scaffolds Promotes Wound Healing

• Main Authors: Gilmartin, Daniel J., Soon, Allyson, Thrasivoulou, Christopher, Phillips, Anthony R. J., Jayasinghe, Suwan N., Becker, David Lawrence
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2016
• Subjects: Tissue Repair; Oligonucleotide Delivery
• Online Access: https://hdl.handle.net/10356/83373; http://hdl.handle.net/10220/41421
• Institution: Nanyang Technological University

Antisense oligodeoxynucleotides targeting the mRNA of the gap junction protein Cx43 promote tissue repair in a variety of different wounds. Delivery of the antisense drug has most often been achieved by a thermoreversible hydrogel, Pluronic F-127, which is very effective in the short term but does n...