A funneled conformational landscape governs flavivirus fusion peptide interaction with lipid membranes

• Main Authors: Marzinek, Jan Kazimierz, Bag, Nirmalya, Huber, Roland G., Holdbrook, Daniel A., Wohland, Thorsten, Verma, Chandra Shekhar, Bond, Peter John
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Biological sciences; Vesicles; Lipids
• Online Access: https://hdl.handle.net/10356/139524
• Institution: Nanyang Technological University

During host cell infection by flaviviruses such as dengue and Zika, acidic pH within the endosome triggers a conformational change in the envelope protein on the outer surface of the virion. This results in exposure of the ∼15 residue fusion peptide (FP) region, freeing it to induce fusion between t...