A funneled conformational landscape governs flavivirus fusion peptide interaction with lipid membranes

• المؤلفون الرئيسيون: Marzinek, Jan Kazimierz, Bag, Nirmalya, Huber, Roland G., Holdbrook, Daniel A., Wohland, Thorsten, Verma, Chandra Shekhar, Bond, Peter John
• مؤلفون آخرون: School of Biological Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2020
• الموضوعات: Science::Biological sciences; Vesicles; Lipids
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/139524
• المؤسسة: Nanyang Technological University

During host cell infection by flaviviruses such as dengue and Zika, acidic pH within the endosome triggers a conformational change in the envelope protein on the outer surface of the virion. This results in exposure of the ∼15 residue fusion peptide (FP) region, freeing it to induce fusion between t...