Three-dimensional graphene biointerface with extremely high sensitivity to single cancer cell monitoring
We developed a three-dimensional biointerface of graphene-based electrical impedance sensor for metastatic cancer diagnosis at single-cell resolution. Compared with traditional impedance sensor with two-dimensional interface, the graphene biointerface mimiced the topography and somatotype features o...
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sg-ntu-dr.10356-1398112020-05-21T09:30:53Z Three-dimensional graphene biointerface with extremely high sensitivity to single cancer cell monitoring Wang, Xiahua Liu, Aiping Xing, Yun Duan, Hongwei Xu, Weizhong Zhou, Qi Wu, Huaping Chen, Cen Chen, Benyong School of Chemical and Biomedical Engineering Engineering::Bioengineering Three-dimensional Graphene Biointerface Electrical Cell-substrate Impedance Sensing (ECIS) We developed a three-dimensional biointerface of graphene-based electrical impedance sensor for metastatic cancer diagnosis at single-cell resolution. Compared with traditional impedance sensor with two-dimensional interface, the graphene biointerface mimiced the topography and somatotype features of cancer cells, achieving more comprehensive and thorough single cell signals in the three-dimensional space. At the nodes of physiological behavior change of single cell, namely cell capture, adhesion, migration and proliferation, the collected electrical signals from graphene biointerface were about two times stronger than those from the two-dimensional gold interface due to the substantial increase in contact area and significant improvement of topographical interaction between cells and graphene electrode. Simultaneous CCD recording and electrical signal extraction from the entrapped single cell on the graphene biointerface enabled to investigate multidimensional cell-electrode interactions and predict cancerous stage and pathology. 2020-05-21T09:30:53Z 2020-05-21T09:30:53Z 2018 Journal Article Wang, X., Liu, A., Xing, Y., Duan, H., Xu, W., Zhou, Q., . . . Chen, B. (2018). Three-dimensional graphene biointerface with extremely high sensitivity to single cancer cell monitoring. Biosensors and Bioelectronics, 105, 22-28. doi:10.1016/j.bios.2018.01.012 0956-5663 https://hdl.handle.net/10356/139811 10.1016/j.bios.2018.01.012 29346077 2-s2.0-85040337809 105 22 28 en Biosensors and Bioelectronics © 2018 Elsevier B.V. All rights reserved. |
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Engineering::Bioengineering Three-dimensional Graphene Biointerface Electrical Cell-substrate Impedance Sensing (ECIS) Wang, Xiahua Liu, Aiping Xing, Yun Duan, Hongwei Xu, Weizhong Zhou, Qi Wu, Huaping Chen, Cen Chen, Benyong Three-dimensional graphene biointerface with extremely high sensitivity to single cancer cell monitoring |
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We developed a three-dimensional biointerface of graphene-based electrical impedance sensor for metastatic cancer diagnosis at single-cell resolution. Compared with traditional impedance sensor with two-dimensional interface, the graphene biointerface mimiced the topography and somatotype features of cancer cells, achieving more comprehensive and thorough single cell signals in the three-dimensional space. At the nodes of physiological behavior change of single cell, namely cell capture, adhesion, migration and proliferation, the collected electrical signals from graphene biointerface were about two times stronger than those from the two-dimensional gold interface due to the substantial increase in contact area and significant improvement of topographical interaction between cells and graphene electrode. Simultaneous CCD recording and electrical signal extraction from the entrapped single cell on the graphene biointerface enabled to investigate multidimensional cell-electrode interactions and predict cancerous stage and pathology. |
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School of Chemical and Biomedical Engineering |
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School of Chemical and Biomedical Engineering Wang, Xiahua Liu, Aiping Xing, Yun Duan, Hongwei Xu, Weizhong Zhou, Qi Wu, Huaping Chen, Cen Chen, Benyong |
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Article |
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Wang, Xiahua Liu, Aiping Xing, Yun Duan, Hongwei Xu, Weizhong Zhou, Qi Wu, Huaping Chen, Cen Chen, Benyong |
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Wang, Xiahua |
title |
Three-dimensional graphene biointerface with extremely high sensitivity to single cancer cell monitoring |
title_short |
Three-dimensional graphene biointerface with extremely high sensitivity to single cancer cell monitoring |
title_full |
Three-dimensional graphene biointerface with extremely high sensitivity to single cancer cell monitoring |
title_fullStr |
Three-dimensional graphene biointerface with extremely high sensitivity to single cancer cell monitoring |
title_full_unstemmed |
Three-dimensional graphene biointerface with extremely high sensitivity to single cancer cell monitoring |
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three-dimensional graphene biointerface with extremely high sensitivity to single cancer cell monitoring |
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2020 |
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https://hdl.handle.net/10356/139811 |
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