A genome-wide association study of diabetic kidney disease in subjects with type 2 diabetes

• Main Authors: van Zuydam, Natalie R., Ahlqvist, Emma, Sandholm, Niina, Deshmukh, Harshal, Rayner, N. William, Abdalla, Moustafa, Ladenvall, Claes, Ziemek, Daniel, Fauman, Eric, Robertson, Neil R., McKeigue, Paul M., Valo, Erkka, Forsblom, Carol, Harjutsalo, Valma, Perna, Annalisa, Rurali, Erica, Marcovecchio, M Loredana, Igo, Robert P., Salem, Rany M., Perico, Norberto, Lajer, Maria, Käräjämäki, Annemari, Imamura, Minako, Kubo, Michiaki, Takahashi, Atsushi, Sim, Xueling, Liu, Jianjun, van Dam, Rob M., Jiang, Guozhi, Tam, Claudia H. T., Luk, Andrea O. Y., Lee, Heung Man, Lim, Cadmon K. P., Szeto, Cheuk Chun, So, Wing Yee, Chan, Juliana C. N., Ang, Su Fen, Dorajoo, Rajkumar, Wang, Ling, Clara, Tan Si Hua, McKnight, Amy-Jayne, Duffy, Seamus, Pezzolesi, Marcus G., Marre, Michel, Gyorgy, Beata, Hadjadj, Samy, Hiraki, Linda T., Ahluwalia, Tarunveer S., Almgren, Peter, Schulz, Christina-Alexandra, Orho-Melander, Marju, Linneberg, Allan, Christensen, Cramer, Witte, Daniel R., Grarup, Niels, Brandslund, Ivan, Melander, Olle, Paterson, Andrew D., Tregouet, David, Maxwell, Alexander P., Lim, Su Chi, Ma, Ronald C. W., Tai, E. Shyong, Maeda, Shiro, Lyssenko, Valeriya, Tuomi, Tiinamaija, Krolewski, Andrzej S., Rich, Stephen S., Hirschhorn, Joel N., Florez, Jose C., Dunger, David, Pedersen, Oluf, Hansen, Torben, Rossing, Peter, Remuzzi, Giuseppe, Brosnan, Mary Julia, Palmer, Colin N. A., Groop, Per-Henrik, Colhoun, Helen M., Groop, Leif C., McCarthy, Mark I.
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Medicine; Diabetes; Diabetic Kidney Disease
• Online Access: https://hdl.handle.net/10356/140035
• Institution: Nanyang Technological University

Identification of sequence variants robustly associated with predisposition to diabetic kidney disease (DKD) has the potential to provide insights into the pathophysiological mechanisms responsible. We conducted a genome-wide association study (GWAS) of DKD in type 2 diabetes (T2D) using eight compl...