Solution structures of a G-quadruplex bound to linear- and cyclic-dinucleotides

• Main Authors: Winnerdy, Fernaldo Richtia, Das, Poulomi, Heddi, Brahim, Phan, Anh Tuân
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Chemistry; Ligands; Genetics
• Online Access: https://hdl.handle.net/10356/140171
• Institution: Nanyang Technological University

Cyclic dinucleotides have emerged as important secondary messengers and cell signaling molecules that regulate several cell responses. A guanine-deficit G-quadruplex structure formation by a sequence containing (4n – 1) guanines, n denoting the number of G-tetrad layers, was previously reported. Her...