Homologous Lympho-epithelial Kazal-type inhibitor domains delay blood coagulation by inhibiting factor X and XI with differential specificity

Despite being initially identified in the blood filtrate, LEKTI is a 15-domain Kazal-type inhibitor mostly known in the regulation of skin desquamation. In the current study, screening of serine proteases in blood coagulation cascade showed that LEKTI domain 4 has inhibitory activity toward only FXI...

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Bibliographic Details
Main Authors: Ramesh, Karthik, Lama, Dilraj, Tan, Kang Wei, Nguyen, Van Sang, Chew, Fook Tim, Verma, Chandra Shekhar, Mok, Yu Keung
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2020
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Online Access:https://hdl.handle.net/10356/140346
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Institution: Nanyang Technological University
Language: English

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