Homologous Lympho-epithelial Kazal-type inhibitor domains delay blood coagulation by inhibiting factor X and XI with differential specificity
Despite being initially identified in the blood filtrate, LEKTI is a 15-domain Kazal-type inhibitor mostly known in the regulation of skin desquamation. In the current study, screening of serine proteases in blood coagulation cascade showed that LEKTI domain 4 has inhibitory activity toward only FXI...
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Main Authors: | Ramesh, Karthik, Lama, Dilraj, Tan, Kang Wei, Nguyen, Van Sang, Chew, Fook Tim, Verma, Chandra Shekhar, Mok, Yu Keung |
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Other Authors: | School of Biological Sciences |
Format: | Article |
Language: | English |
Published: |
2020
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Subjects: | |
Online Access: | https://hdl.handle.net/10356/140346 |
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Institution: | Nanyang Technological University |
Language: | English |
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