Homologous Lympho-epithelial Kazal-type inhibitor domains delay blood coagulation by inhibiting factor X and XI with differential specificity

• Main Authors: Ramesh, Karthik, Lama, Dilraj, Tan, Kang Wei, Nguyen, Van Sang, Chew, Fook Tim, Verma, Chandra Shekhar, Mok, Yu Keung
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Biological sciences; Lympho-epithelial Kazal-type related inhibitor; Factor Xa
• Online Access: https://hdl.handle.net/10356/140346
• Institution: Nanyang Technological University

Despite being initially identified in the blood filtrate, LEKTI is a 15-domain Kazal-type inhibitor mostly known in the regulation of skin desquamation. In the current study, screening of serine proteases in blood coagulation cascade showed that LEKTI domain 4 has inhibitory activity toward only FXI...