One-step solid-oil-water emulsion for sustained bioactive ranibizumab release

• Main Authors: Chua, Hui Yee, Lui, Yuan Siang, Bhuthalingam, Ramya, Agrawal, Rupesh, Wong, Tina, Preiser, Peter Rainer, Venkatraman, Subbu
• Other Authors: School of Materials Science & Engineering
• Format: Article
• Language: English
• Published: 2020
• Subjects: Engineering::Materials; Bioactive; PLGA
• Online Access: https://hdl.handle.net/10356/140611
• Institution: Nanyang Technological University

Background: The advent of therapeutic proteins highlights the need for delivery systems that protect and extend the duration of its action. Ranibizumab-VEGF is one such drug used for treating wet AMD. This paper describes a facile method to sustain bioactive ranibizumab release from PLGA-based parti...