Does oxidative stress contribute to adverse outcomes in HIV-associated TB?

Does oxidative stress contribute to adverse outcomes in HIV-associated TB?

In HIV infection, oxidative stress is a pronounced phenomenon, with likely links to HIV-related pathologies and the progression of HIV infection per se. TB is an AIDS-defining condition. HIV-associated oxidative stress, like that associated with diabetes mellitus, might adversely impact the outcomes...

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Bibliographic Details
Main Authors: Yew, Wing-Wai, Chan, Denise Puichung, Singhal, Amit, Zhang, Ying, Lee, Shui-Shan
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Article
Language:English
Published: 2020
Subjects:
Science::Medicine
Oxidative Stress
HIV
Online Access:https://hdl.handle.net/10356/141007
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Institution: Nanyang Technological University
Language: English
Description
Summary:In HIV infection, oxidative stress is a pronounced phenomenon, with likely links to HIV-related pathologies and the progression of HIV infection per se. TB is an AIDS-defining condition. HIV-associated oxidative stress, like that associated with diabetes mellitus, might adversely impact the outcomes of TB, probably through increased propensity for generation of metabolically dormant mycobacterial persisters, alongside other mechanisms. This hypothesis might help in guiding the exploration of relevant research directions to improve the care of patients.

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