Does oxidative stress contribute to adverse outcomes in HIV-associated TB?

Does oxidative stress contribute to adverse outcomes in HIV-associated TB?

In HIV infection, oxidative stress is a pronounced phenomenon, with likely links to HIV-related pathologies and the progression of HIV infection per se. TB is an AIDS-defining condition. HIV-associated oxidative stress, like that associated with diabetes mellitus, might adversely impact the outcomes...

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Main Authors: Yew, Wing-Wai, Chan, Denise Puichung, Singhal, Amit, Zhang, Ying, Lee, Shui-Shan
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Article
Language:English
Published: 2020
Subjects:
Science::Medicine
Oxidative Stress
HIV
Online Access:https://hdl.handle.net/10356/141007
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Institution: Nanyang Technological University
Language: English
id sg-ntu-dr.10356-141007
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spelling sg-ntu-dr.10356-1410072020-06-03T06:52:07Z Does oxidative stress contribute to adverse outcomes in HIV-associated TB? Yew, Wing-Wai Chan, Denise Puichung Singhal, Amit Zhang, Ying Lee, Shui-Shan Lee Kong Chian School of Medicine (LKCMedicine) Science::Medicine Oxidative Stress HIV In HIV infection, oxidative stress is a pronounced phenomenon, with likely links to HIV-related pathologies and the progression of HIV infection per se. TB is an AIDS-defining condition. HIV-associated oxidative stress, like that associated with diabetes mellitus, might adversely impact the outcomes of TB, probably through increased propensity for generation of metabolically dormant mycobacterial persisters, alongside other mechanisms. This hypothesis might help in guiding the exploration of relevant research directions to improve the care of patients. ASTAR (Agency for Sci., Tech. and Research, S’pore) 2020-06-03T06:52:07Z 2020-06-03T06:52:07Z 2018 Journal Article Yew, W.-W., Chan, D. P., Singhal, A., Zhang, Y., & Lee, S.-S. (2018). Does oxidative stress contribute to adverse outcomes in HIV-associated TB? Journal of Antimicrobial Chemotherapy, 73(5), 1117-1120. doi:10.1093/jac/dkx509 0305-7453 https://hdl.handle.net/10356/141007 10.1093/jac/dkx509 29325139 2-s2.0-85047020108 5 73 1117 1120 en Journal of Antimicrobial Chemotherapy © 2018 The Author(s) (published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy). All rights reserved.
institution Nanyang Technological University
building NTU Library
country Singapore
collection DR-NTU
language English
topic Science::Medicine
Oxidative Stress
HIV
spellingShingle Science::Medicine
Oxidative Stress
HIV
Yew, Wing-Wai
Chan, Denise Puichung
Singhal, Amit
Zhang, Ying
Lee, Shui-Shan
Does oxidative stress contribute to adverse outcomes in HIV-associated TB?
description In HIV infection, oxidative stress is a pronounced phenomenon, with likely links to HIV-related pathologies and the progression of HIV infection per se. TB is an AIDS-defining condition. HIV-associated oxidative stress, like that associated with diabetes mellitus, might adversely impact the outcomes of TB, probably through increased propensity for generation of metabolically dormant mycobacterial persisters, alongside other mechanisms. This hypothesis might help in guiding the exploration of relevant research directions to improve the care of patients.
author2 Lee Kong Chian School of Medicine (LKCMedicine)
author_facet Lee Kong Chian School of Medicine (LKCMedicine)
Yew, Wing-Wai
Chan, Denise Puichung
Singhal, Amit
Zhang, Ying
Lee, Shui-Shan
format Article
author Yew, Wing-Wai
Chan, Denise Puichung
Singhal, Amit
Zhang, Ying
Lee, Shui-Shan
author_sort Yew, Wing-Wai
title Does oxidative stress contribute to adverse outcomes in HIV-associated TB?
title_short Does oxidative stress contribute to adverse outcomes in HIV-associated TB?
title_full Does oxidative stress contribute to adverse outcomes in HIV-associated TB?
title_fullStr Does oxidative stress contribute to adverse outcomes in HIV-associated TB?
title_full_unstemmed Does oxidative stress contribute to adverse outcomes in HIV-associated TB?
title_sort does oxidative stress contribute to adverse outcomes in hiv-associated tb?
publishDate 2020
url https://hdl.handle.net/10356/141007
_version_ 1681059015258275840

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