No association of DNM3 with age of onset in Asian Parkinson's disease

• Main Authors: Foo, Jia Nee, Tan, Louis C., Au, Wing-Lok, Prakash, Kumar-M., Liu, Jianjun, Tan, Eng-King
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Biological sciences::Genetics; Parkinson's Disease; Human Genetics
• Online Access: https://hdl.handle.net/10356/141196
• Institution: Nanyang Technological University

Background: Genetic variability in DNM3 have been shown to modify age of onset of Parkinson’s disease (PD) among LRRK2 Gly2019Ser carriers in North African Arab-Berber populations. In Asian populations, the Gly2019Ser mutation is rare or absent but two other LRRK2 variants Gly2385Arg and Arg1628PPro...