Structural analysis of protein tyrosine phosphatase 1B reveals potentially druggable allosteric binding sites

• المؤلفون الرئيسيون: Kumar, Ammu Prasanna, Nguyen, Minh Nhan, Verma, Chandra, Lukman, Suryani
• مؤلفون آخرون: School of Biological Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2020
• الموضوعات: Science::Biological sciences; Allosteric Site; Binding Site
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/141772
• المؤسسة: Nanyang Technological University

Catalytic proteins such as human protein tyrosine phosphatase 1B (PTP1B), with conserved and highly polar active sites, warrant the discovery of druggable nonactive sites, such as allosteric sites, and potentially, therapeutic small molecules that can bind to these sites. Catalyzing the dephosphoryl...