Conformational landscape of the epidermal growth factor receptor kinase reveals a mutant specific allosteric pocket
Activating mutations within the epidermal growth factor receptor (EGFR) kinase domain give rise to several cancers including Non-Small Cell Lung Cancer (NSCLC). Small molecule inhibitors targeted at these mutants have proven to be clinically successful drugs. These molecules are ATP competitive and...
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Main Authors: | , , , , |
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Other Authors: | |
Format: | Article |
Language: | English |
Published: |
2018
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Subjects: | |
Online Access: | https://hdl.handle.net/10356/87563 http://hdl.handle.net/10220/45403 |
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Institution: | Nanyang Technological University |
Language: | English |