Conformational landscape of the epidermal growth factor receptor kinase reveals a mutant specific allosteric pocket

• المؤلفون الرئيسيون: Kannan, Srinivasaraghavan, Venkatachalam, Gireedhar, Lim, Hong Hwa, Surana, Uttam, Verma, Chandra
• مؤلفون آخرون: School of Biological Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2018
• الموضوعات: Allosteric Pocket; Molecular Dynamics Simulation
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/87563; http://hdl.handle.net/10220/45403
• المؤسسة: Nanyang Technological University

Activating mutations within the epidermal growth factor receptor (EGFR) kinase domain give rise to several cancers including Non-Small Cell Lung Cancer (NSCLC). Small molecule inhibitors targeted at these mutants have proven to be clinically successful drugs. These molecules are ATP competitive and...