Conformational landscape of the epidermal growth factor receptor kinase reveals a mutant specific allosteric pocket

• Main Authors: Kannan, Srinivasaraghavan, Venkatachalam, Gireedhar, Lim, Hong Hwa, Surana, Uttam, Verma, Chandra
• 其他作者: School of Biological Sciences
• 格式: Article
• 語言: English
• 出版: 2018
• 主題: Allosteric Pocket; Molecular Dynamics Simulation
• 在線閱讀: https://hdl.handle.net/10356/87563; http://hdl.handle.net/10220/45403

Activating mutations within the epidermal growth factor receptor (EGFR) kinase domain give rise to several cancers including Non-Small Cell Lung Cancer (NSCLC). Small molecule inhibitors targeted at these mutants have proven to be clinically successful drugs. These molecules are ATP competitive and...