Conformational landscape of the epidermal growth factor receptor kinase reveals a mutant specific allosteric pocket

• Main Authors: Kannan, Srinivasaraghavan, Venkatachalam, Gireedhar, Lim, Hong Hwa, Surana, Uttam, Verma, Chandra
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2018
• Subjects: Allosteric Pocket; Molecular Dynamics Simulation
• Online Access: https://hdl.handle.net/10356/87563; http://hdl.handle.net/10220/45403
• Institution: Nanyang Technological University

Activating mutations within the epidermal growth factor receptor (EGFR) kinase domain give rise to several cancers including Non-Small Cell Lung Cancer (NSCLC). Small molecule inhibitors targeted at these mutants have proven to be clinically successful drugs. These molecules are ATP competitive and...