Amorphous nanoparticle complex of perphenazine and dextran sulfate as a new solubility enhancement strategy of antipsychotic perphenazine

Amorphous nanoparticle complex of perphenazine and dextran sulfate as a new solubility enhancement strategy of antipsychotic perphenazine

Objective: The objective of this study is to develop a new solubility enhancement strategy of anti- psychotic drug – perphenazine (PPZ) – in the form of its amorphous nanoparticle complex (or nanoplex) with polyelectrolyte dextran sulfate (DXT). Significance: Poor bioavailability of PPZ necessitated...

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Bibliographic Details
Main Authors: Dong, Bingxue, Hadinoto, Kunn
Other Authors: School of Chemical and Biomedical Engineering
Format: Article
Language:English
Published: 2020
Subjects:
Pharmacy
Engineering::Chemical engineering
Amorphization
Supersaturation
Online Access:https://hdl.handle.net/10356/141825
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Institution: Nanyang Technological University
Language: English

Internet

https://hdl.handle.net/10356/141825

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