Amorphous nanoparticle complex of perphenazine and dextran sulfate as a new solubility enhancement strategy of antipsychotic perphenazine

• Main Authors: Dong, Bingxue, Hadinoto, Kunn
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2020
• Subjects: Pharmacy; Engineering::Chemical engineering; Amorphization; Supersaturation
• Online Access: https://hdl.handle.net/10356/141825
• Institution: Nanyang Technological University

Objective: The objective of this study is to develop a new solubility enhancement strategy of anti- psychotic drug – perphenazine (PPZ) – in the form of its amorphous nanoparticle complex (or nanoplex) with polyelectrolyte dextran sulfate (DXT). Significance: Poor bioavailability of PPZ necessitated...