Modulating macrophage phenotype by sustained microRNA delivery improves host‐implant integration

• Main Authors: Lin, Junquan, Ibrahim Mohamed, Lin, Po Hen, Shirahama, Hitomi, Milbreta, Ulla, Sieow, Je Lin, Peng, Yanfen, Bugiani, Marianna, Wong, Siew Cheng, Levinson, Howard, Chew, Sing Yian
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2020
• Subjects: Engineering::Bioengineering; Electrospinning; Fibrous Capsule Formation
• Online Access: https://hdl.handle.net/10356/142010
• Institution: Nanyang Technological University

Biomedical implant failure due to the host's response remains a challenging problem. In particular, the formation of the fibrous capsule is a common barrier for the normal function of implants. Currently, there is mounting evidence indicating that the polarization state of macrophages plays an...