The BEACH domain is critical for blue cheese function in a spatial and epistatic autophagy hierarchy
Drosophila blue cheese (bchs) encodes a BEACH domain adaptor protein that, like its human homolog ALFY, promotes clearance of aggregated proteins through its interaction with Atg5 and p62. bchs mutations lead to age-dependent accumulation of ubiquitinated inclusions and progressive neurodegeneration...
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Main Authors: | Sim, Joan, Osborne, Kathleen Amy, García, Irene Argudo, Matysik, Artur Stanislaw, Kraut, Rachel |
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Other Authors: | School of Biological Sciences |
Format: | Article |
Language: | English |
Published: |
2020
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Subjects: | |
Online Access: | https://hdl.handle.net/10356/142101 |
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Institution: | Nanyang Technological University |
Language: | English |
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