The BEACH domain is critical for blue cheese function in a spatial and epistatic autophagy hierarchy

• المؤلفون الرئيسيون: Sim, Joan, Osborne, Kathleen Amy, García, Irene Argudo, Matysik, Artur Stanislaw, Kraut, Rachel
• مؤلفون آخرون: School of Biological Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2020
• الموضوعات: Science::Biological sciences; Blue Cheese; Drosophila
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/142101
• المؤسسة: Nanyang Technological University

Drosophila blue cheese (bchs) encodes a BEACH domain adaptor protein that, like its human homolog ALFY, promotes clearance of aggregated proteins through its interaction with Atg5 and p62. bchs mutations lead to age-dependent accumulation of ubiquitinated inclusions and progressive neurodegeneration...