The potential of the FSP1cre-Pparb/d-/- mouse model for studying juvenile NAFLD

• Main Authors: Chen, Jiapeng, Zhuang, Yan, Sng, Ming Keat, Tan, Nguan Soon, Wahli, Walter
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Medicine; Pparb/d; FSP1
• Online Access: https://hdl.handle.net/10356/142227
• Institution: Nanyang Technological University

Non-alcoholic fatty liver disease (NAFLD) can progress from steatosis to non-alcoholic steatohepatitis (NASH) characterized by liver inflammation, possibly leading to cirrhosis and hepatocellular carcinoma (HCC). Mice with impaired macrophage activation, when fed a high-fat diet, develop severe NASH...