The expression of four pyridoxal kinase (PDXK) human variants in Drosophila impacts on genome integrity

In eukaryotes, pyridoxal kinase (PDXK) acts in vitamin B6 salvage pathway to produce pyridoxal 5'-phosphate (PLP), the active form of the vitamin, which is implicated in numerous crucial metabolic reactions. In Drosophila, mutations in the dPdxk gene cause chromosome aberrations (CABs) and incr...

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Main Authors: Mascolo, Elisa, Barile, Anna, Mecarelli, Lorenzo Stufera, Amoroso, Noemi, Merigliano, Chiara, Massimi, Arianna, Saggio, Isabella, Hansen, Torben, Tramonti, Angela, Di Salvo, Martino Luigi, Barbetti, Fabrizio, Contestabile, Roberto, Vernì, Fiammetta
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2020
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Online Access:https://hdl.handle.net/10356/142344
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Institution: Nanyang Technological University
Language: English