The expression of four pyridoxal kinase (PDXK) human variants in Drosophila impacts on genome integrity

• Main Authors: Mascolo, Elisa, Barile, Anna, Mecarelli, Lorenzo Stufera, Amoroso, Noemi, Merigliano, Chiara, Massimi, Arianna, Saggio, Isabella, Hansen, Torben, Tramonti, Angela, Di Salvo, Martino Luigi, Barbetti, Fabrizio, Contestabile, Roberto, Vernì, Fiammetta
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Biological sciences; Pyridoxal Kinase (PDXK)
• Online Access: https://hdl.handle.net/10356/142344
• Institution: Nanyang Technological University

In eukaryotes, pyridoxal kinase (PDXK) acts in vitamin B6 salvage pathway to produce pyridoxal 5'-phosphate (PLP), the active form of the vitamin, which is implicated in numerous crucial metabolic reactions. In Drosophila, mutations in the dPdxk gene cause chromosome aberrations (CABs) and incr...