Biguanide-derived polymeric nanoparticles kill MRSA biofilm and suppress infection in vivo

• Main Authors: Li, Jianghua, Zhong, Wenbin, Zhang, Kaixi, Wang, Dongwei, Hu, Jingbo, Chan-Park, Mary B.
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2020
• Subjects: Engineering::Chemical engineering; Antibiofilm; Biocompatibility
• Online Access: https://hdl.handle.net/10356/142365
• Institution: Nanyang Technological University

Methicillin-resistant Staphylococcus aureus (MRSA) is a significant cause of drug-resistant infections. Its propensity to develop biofilms makes it especially resistant to conventional antibiotics. We present a novel nanoparticle (NP) system made from biocompatible F-127 surfactant, tannic acid (TA)...