Mimicking immune signatures of flavivirus infection with targeted adjuvants improves dengue subunit vaccine immunogenicity

• Main Authors: Bidet, Katell, Ho, Victor, Chu, Collins Wenhan, Ahmad Nazri Mohamed Naim, Thazin, Khaing, Chan, Kuan Rong, Low, Jenny G. H., Choy, Milly M., Wong, Lan Hiong, de Sessions, Paola Florez, Lee, Yie Hou, Hibberd, Martin L., Ooi, Eng Eong, Fink, Katja, Chen, Jianzhu
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Biological sciences; Flavivirus Infection; Vaccine Immunogenicity
• Online Access: https://hdl.handle.net/10356/142456
• Institution: Nanyang Technological University

Neutralizing antibodies (nAbs) are a critical component for protection against dengue virus (DENV) infection, but little is known about the immune mechanisms governing their induction and whether such mechanisms can be harnessed for vaccine development. In this study, we profiled the early immune re...