The mutator phenotype : adapting microbial evolution to cancer biology

The mutator phenotype hypothesis was postulated almost 40 years ago to reconcile the observation that while cancer cells display widespread mutational burden, acquisition of mutations in non-transformed cells is a rare event. Moreover, it also suggested that cancer evolution could be fostered by inc...

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Bibliographic Details
Main Authors: Natali, Federica, Rancati, Giulia
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2020
Subjects:
Online Access:https://hdl.handle.net/10356/142479
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Institution: Nanyang Technological University
Language: English