The mutator phenotype : adapting microbial evolution to cancer biology

• المؤلفون الرئيسيون: Natali, Federica, Rancati, Giulia
• مؤلفون آخرون: School of Biological Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2020
• الموضوعات: Science::Biological sciences; Mutator Phenotype; Cell-to-cell Heterogeneity
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/142479

The mutator phenotype hypothesis was postulated almost 40 years ago to reconcile the observation that while cancer cells display widespread mutational burden, acquisition of mutations in non-transformed cells is a rare event. Moreover, it also suggested that cancer evolution could be fostered by inc...