The mutator phenotype : adapting microbial evolution to cancer biology

• Main Authors: Natali, Federica, Rancati, Giulia
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Biological sciences; Mutator Phenotype; Cell-to-cell Heterogeneity
• Online Access: https://hdl.handle.net/10356/142479
• Institution: Nanyang Technological University

The mutator phenotype hypothesis was postulated almost 40 years ago to reconcile the observation that while cancer cells display widespread mutational burden, acquisition of mutations in non-transformed cells is a rare event. Moreover, it also suggested that cancer evolution could be fostered by inc...