Self-association and conformational variation of NS5A domain 1 of hepatitis C virus

• المؤلفون الرئيسيون: Beldar, Serap, Manimekalai, Malathy Sony Subramanian, Cho, Nam-Joon, Baek, Kwanghee, Grüber, Gerhard, Yoon, Ho Sup
• مؤلفون آخرون: School of Materials Science and Engineering
• التنسيق: مقال
• اللغة: English
• منشور في: 2020
• الموضوعات: Science::Biological sciences; Hepatitis C Virus; NS5A Protein
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/142589

Direct-acting antivirals (DAAs) targeting the non-structural 5A (NS5A) protein of the hepatitis C virus (HCV) are crucial drugs that have shown exceptional clinical success in patients. However, their mode of action (MoA) remains unclear, and drug-resistant HCV strains are rapidly emerging. It is cr...