Self-association and conformational variation of NS5A domain 1 of hepatitis C virus

• Main Authors: Beldar, Serap, Manimekalai, Malathy Sony Subramanian, Cho, Nam-Joon, Baek, Kwanghee, Grüber, Gerhard, Yoon, Ho Sup
• Other Authors: School of Materials Science and Engineering
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Biological sciences; Hepatitis C Virus; NS5A Protein
• Online Access: https://hdl.handle.net/10356/142589
• Institution: Nanyang Technological University

Direct-acting antivirals (DAAs) targeting the non-structural 5A (NS5A) protein of the hepatitis C virus (HCV) are crucial drugs that have shown exceptional clinical success in patients. However, their mode of action (MoA) remains unclear, and drug-resistant HCV strains are rapidly emerging. It is cr...