Structure of the NS2B-NS3 protease from Zika virus after self-cleavage

• Main Authors: Phoo, Wint Wint, Li, Yan, Zhang, Zhenzhen, Lee, Michelle Yueqi, Loh, Ying Ru, Tan, Yaw Bia, Ng, Elizabeth Yihui, Lescar, Julien, Kang, CongBao, Luo, Dahai
• 其他作者: School of Biological Sciences
• 格式: Article
• 語言: English
• 出版: 2017
• 主題: Zika virus; NS2B-NS3
• 在線閱讀: https://hdl.handle.net/10356/83027; http://hdl.handle.net/10220/42379
• 機構: Nanyang Technological University

The recent outbreak of Zika virus (ZIKV) infections in the Americas represents a serious threat to the global public health. The viral protease that processes viral polyproteins during infection appears as an attractive drug target. Here we report a crystal structure at 1.84 Å resolution of ZIKV non...