Nucleic acid structure and conjugation for drug design

• Main Author: Tan, Derrick Jing Yang
• Other Authors: Phan Anh Tuan
• Format: Thesis-Doctor of Philosophy
• Language: English
• Published: Nanyang Technological University 2020
• Subjects: Science::Chemistry::Biochemistry
• Online Access: https://hdl.handle.net/10356/143056
• Institution: Nanyang Technological University

Nucleic acids can adopt diverse secondary structures, one of which is the four-stranded G-quadruplex (G4). The G4s have been widely studied as anticancer targets where their stabilization by ligands were shown to impact downstream biological processes. Recent discoveries of G4 sub-types, such as qua...