AIE featured inorganic-organic Core@Shell nanoparticles for high-efficiency siRNA delivery and real-time monitoring

RNA interference (RNAi) is demonstrated as one of the most powerful technologies for sequence-specific suppression of genes in disease therapeutics. Exploration of novel vehicles for small interfering RNA (siRNA) delivery with high efficiency, low cytotoxicity, and self-monitoring functionality is p...

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Main Authors: He, Xuewen, Yin, Feng, Wang, Dongyuan, Xiong, Ling-Hong, Kwok, Ryan T. K., Gao, Peng Fei, Zhao, Zheng, Lam, Jacky W. Y., Yong, Ken-Tye, Li, Zigang, Tang, Ben Zhong
Other Authors: School of Electrical and Electronic Engineering
Format: Article
Language:English
Published: 2020
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Online Access:https://hdl.handle.net/10356/143658
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-1436582020-09-15T07:21:54Z AIE featured inorganic-organic Core@Shell nanoparticles for high-efficiency siRNA delivery and real-time monitoring He, Xuewen Yin, Feng Wang, Dongyuan Xiong, Ling-Hong Kwok, Ryan T. K. Gao, Peng Fei Zhao, Zheng Lam, Jacky W. Y. Yong, Ken-Tye Li, Zigang Tang, Ben Zhong School of Electrical and Electronic Engineering Engineering::Electrical and electronic engineering Aggregation-induced Emission Nanocarrier RNA interference (RNAi) is demonstrated as one of the most powerful technologies for sequence-specific suppression of genes in disease therapeutics. Exploration of novel vehicles for small interfering RNA (siRNA) delivery with high efficiency, low cytotoxicity, and self-monitoring functionality is persistently pursued. Herein, by taking advantage of aggregation-induced emission luminogen (AIEgen), we developed a novel class of Ag@AIE core@shell nanocarriers with regulable and uniform morphology. It presented excellent efficiencies in siRNA delivery, target gene knockdown, and cancer cell inhibition in vitro. What's more, an anticancer efficacy up to 75% was achieved in small animal experiments without obvious toxicity. Attributing to the unique AIE properties, real-time intracellular tracking of siRNA delivery and long-term tumor tissue imaging were successfully realized. Compared to the commercial transfection reagents, significant improvements were obtained in biocompatibility, delivery efficiency, and reproducibility, representing a promising future of this nanocarrier in RNAi-related cancer therapeutics. Accepted version The authors acknowledge funding to B.Z.T. from the Innovation and Technology Commission (ITCCNERC14SC01 and ITS/254117), the National Science Foundation of China (NSFC 21788102), and the Research Grants Council of Hong Kong (16305015, N_HKUST604/14, A-HKUST605/16, and C6009-17G). B.Z.T. is also grateful for the support from the Science and Technology Plan of Shenzhen (JCYJ20160229205601482). The authors also acknowledge funding to Z.L. (NSFC 1778009), F.Y. (NSFC 81701818), and L.-H.X. (NSFC 21705111). 2020-09-15T07:19:55Z 2020-09-15T07:19:55Z 2019 Journal Article He, X., Yin, F., Wang, D., Xiong, L.-H., Kwok, R. T. K., Gao, P. F., . . . Tang, B. Z. (2019).AIE featured inorganic-organic Core@Shell nanoparticles for high-efficiency siRNA delivery and real-time monitoring. Nano Letters, 19(4), 2272-2279. doi:10.1021/acs.nanolett.8b04677 1530-6984 https://hdl.handle.net/10356/143658 10.1021/acs.nanolett.8b04677 30829039 4 19 2272 2279 en Nano Letters This document is the Accepted Manuscript version of a Published Work that appeared in final form in Nano Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.nanolett.8b04677 application/pdf
institution Nanyang Technological University
building NTU Library
country Singapore
collection DR-NTU
language English
topic Engineering::Electrical and electronic engineering
Aggregation-induced Emission
Nanocarrier
spellingShingle Engineering::Electrical and electronic engineering
Aggregation-induced Emission
Nanocarrier
He, Xuewen
Yin, Feng
Wang, Dongyuan
Xiong, Ling-Hong
Kwok, Ryan T. K.
Gao, Peng Fei
Zhao, Zheng
Lam, Jacky W. Y.
Yong, Ken-Tye
Li, Zigang
Tang, Ben Zhong
AIE featured inorganic-organic Core@Shell nanoparticles for high-efficiency siRNA delivery and real-time monitoring
description RNA interference (RNAi) is demonstrated as one of the most powerful technologies for sequence-specific suppression of genes in disease therapeutics. Exploration of novel vehicles for small interfering RNA (siRNA) delivery with high efficiency, low cytotoxicity, and self-monitoring functionality is persistently pursued. Herein, by taking advantage of aggregation-induced emission luminogen (AIEgen), we developed a novel class of Ag@AIE core@shell nanocarriers with regulable and uniform morphology. It presented excellent efficiencies in siRNA delivery, target gene knockdown, and cancer cell inhibition in vitro. What's more, an anticancer efficacy up to 75% was achieved in small animal experiments without obvious toxicity. Attributing to the unique AIE properties, real-time intracellular tracking of siRNA delivery and long-term tumor tissue imaging were successfully realized. Compared to the commercial transfection reagents, significant improvements were obtained in biocompatibility, delivery efficiency, and reproducibility, representing a promising future of this nanocarrier in RNAi-related cancer therapeutics.
author2 School of Electrical and Electronic Engineering
author_facet School of Electrical and Electronic Engineering
He, Xuewen
Yin, Feng
Wang, Dongyuan
Xiong, Ling-Hong
Kwok, Ryan T. K.
Gao, Peng Fei
Zhao, Zheng
Lam, Jacky W. Y.
Yong, Ken-Tye
Li, Zigang
Tang, Ben Zhong
format Article
author He, Xuewen
Yin, Feng
Wang, Dongyuan
Xiong, Ling-Hong
Kwok, Ryan T. K.
Gao, Peng Fei
Zhao, Zheng
Lam, Jacky W. Y.
Yong, Ken-Tye
Li, Zigang
Tang, Ben Zhong
author_sort He, Xuewen
title AIE featured inorganic-organic Core@Shell nanoparticles for high-efficiency siRNA delivery and real-time monitoring
title_short AIE featured inorganic-organic Core@Shell nanoparticles for high-efficiency siRNA delivery and real-time monitoring
title_full AIE featured inorganic-organic Core@Shell nanoparticles for high-efficiency siRNA delivery and real-time monitoring
title_fullStr AIE featured inorganic-organic Core@Shell nanoparticles for high-efficiency siRNA delivery and real-time monitoring
title_full_unstemmed AIE featured inorganic-organic Core@Shell nanoparticles for high-efficiency siRNA delivery and real-time monitoring
title_sort aie featured inorganic-organic core@shell nanoparticles for high-efficiency sirna delivery and real-time monitoring
publishDate 2020
url https://hdl.handle.net/10356/143658
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