Visible light-mediated trifluoromethylation of fluorinated alkenes via C−F bond cleavage
A convenient photoredox‐catalyzed defluorinative trifluoromethylation of α‐trifluoromethyl alkenes and gem‐difluoroalkenes is developed. The reactions proceeded efficiently via trifluoromethyl radical addition followed by β‐fluorine elimination process, providing a new entry to multifluorinated alke...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
2020
|
| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/143698 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Institution: | Nanyang Technological University |
| Language: | English |
| id |
sg-ntu-dr.10356-143698 |
|---|---|
| record_format |
dspace |
| spelling |
sg-ntu-dr.10356-1436982020-09-17T03:07:58Z Visible light-mediated trifluoromethylation of fluorinated alkenes via C−F bond cleavage Wu, Liu-Hai Cheng, Jun-Kee Shen, Liang Shen, Zhi-Liang Loh, Teck-Peng School of Physical and Mathematical Sciences Engineering::Chemical engineering Photocatalysis C−F Bond Cleavage A convenient photoredox‐catalyzed defluorinative trifluoromethylation of α‐trifluoromethyl alkenes and gem‐difluoroalkenes is developed. The reactions proceeded efficiently via trifluoromethyl radical addition followed by β‐fluorine elimination process, providing a new entry to multifluorinated alkenes in moderate to good yields with excellent stereoselectivity. Ministry of Education (MOE) 2020-09-17T03:07:58Z 2020-09-17T03:07:58Z 2018 Journal Article Wu, L.-H., Cheng, J.-K., Shen, L., Shen, Z.-L., & Loh, T.-P. (2018). Visible light-mediated trifluoromethylation of fluorinated alkenes via C−F bond cleavage. Advanced Synthesis & Catalysis, 360(20), 3894-3899. doi:10.1002/adsc.201800740 1615-4169 https://hdl.handle.net/10356/143698 10.1002/adsc.201800740 20 360 3894 3899 en Advanced Synthesis & Catalysis © 2018 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim. All rights reserved. |
| institution |
Nanyang Technological University |
| building |
NTU Library |
| country |
Singapore |
| collection |
DR-NTU |
| language |
English |
| topic |
Engineering::Chemical engineering Photocatalysis C−F Bond Cleavage |
| spellingShingle |
Engineering::Chemical engineering Photocatalysis C−F Bond Cleavage Wu, Liu-Hai Cheng, Jun-Kee Shen, Liang Shen, Zhi-Liang Loh, Teck-Peng Visible light-mediated trifluoromethylation of fluorinated alkenes via C−F bond cleavage |
| description |
A convenient photoredox‐catalyzed defluorinative trifluoromethylation of α‐trifluoromethyl alkenes and gem‐difluoroalkenes is developed. The reactions proceeded efficiently via trifluoromethyl radical addition followed by β‐fluorine elimination process, providing a new entry to multifluorinated alkenes in moderate to good yields with excellent stereoselectivity. |
| author2 |
School of Physical and Mathematical Sciences |
| author_facet |
School of Physical and Mathematical Sciences Wu, Liu-Hai Cheng, Jun-Kee Shen, Liang Shen, Zhi-Liang Loh, Teck-Peng |
| format |
Article |
| author |
Wu, Liu-Hai Cheng, Jun-Kee Shen, Liang Shen, Zhi-Liang Loh, Teck-Peng |
| author_sort |
Wu, Liu-Hai |
| title |
Visible light-mediated trifluoromethylation of fluorinated alkenes via C−F bond cleavage |
| title_short |
Visible light-mediated trifluoromethylation of fluorinated alkenes via C−F bond cleavage |
| title_full |
Visible light-mediated trifluoromethylation of fluorinated alkenes via C−F bond cleavage |
| title_fullStr |
Visible light-mediated trifluoromethylation of fluorinated alkenes via C−F bond cleavage |
| title_full_unstemmed |
Visible light-mediated trifluoromethylation of fluorinated alkenes via C−F bond cleavage |
| title_sort |
visible light-mediated trifluoromethylation of fluorinated alkenes via c−f bond cleavage |
| publishDate |
2020 |
| url |
https://hdl.handle.net/10356/143698 |
| _version_ |
1681058512987226112 |