Metabonomic investigation of biological effects of a new vessel target protein tTF-pHLIP in a mouse model

• Main Authors: Ding, Laifeng, Zhang, Congcong, Liu, Zhigang, Huang, Qingxia, Zhang, Yinlong, Li, Suping, Nie, Guangjun, Tang, Huiru, Wang, Yulan
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Medicine; Vessel Target Protein; Biological Effects
• Online Access: https://hdl.handle.net/10356/144048
• Institution: Nanyang Technological University

In recent years, tumor microenvironment (TME) has been recognized as potential targets for tumor treatment and the tumor vascular system is one of such targets. Fusing truncated tissue factor (tTF) with pH low insertion peptides (pHLIP), tTF-pHLIP, can target tumor vessels owing to its acidic TME an...