Small molecule anti-biofilm agents developed on the basis of mechanistic understanding of biofilm formation

• Main Authors: Qvortrup, Katrine, Hultqvist, Louise Dahl, Nilsson, Martin, Jakobsen, Tim Holm, Jansen, Charlotte Uldahl, Uhd, Jesper, Andersen, Jens Bo, Nielsen, Thomas Eiland, Givskov, Michael, Tolker-Nielsen, Tim
• Other Authors: Singapore Centre for Environmental Life Sciences and Engineering
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::General; Pseudomonas Aeruginosa; Escherichia Coli
• Online Access: https://hdl.handle.net/10356/144050
• Institution: Nanyang Technological University

Microbial biofilms are the cause of persistent infections associated with various medical implants and distinct body sites such as the urinary tract, lungs, and wounds. Compared with their free living counterparts, bacteria in biofilms display a highly increased resistance to immune system activitie...