Role of Lipopolysaccharide in protecting OmpT from autoproteolysis during in vitro refolding

Outer membrane protease (OmpT) is a 33.5 kDa aspartyl protease that cleaves at dibasic sites and is thought to function as a defense mechanism for E. coli against cationic antimicrobial peptides secreted by the host immune system. Despite carrying three dibasic sites in its own sequence, there is no...

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Bibliographic Details
Main Authors: Sinsinbar, Gaurav, Gudlur, Sushanth, Metcalf, Kevin J., Mrksich, Milan, Nallani, Madhavan, Liedberg, Bo
Other Authors: School of Materials Science and Engineering
Format: Article
Language:English
Published: 2020
Subjects:
LPS
Online Access:https://hdl.handle.net/10356/144253
https://doi.org/10.3390/biom10060922
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Institution: Nanyang Technological University
Language: English

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