Dihydropyrrolones as bacterial quorum sensing inhibitors

• Main Authors: Almohaywi, Basmah, Yu, Tsz Tin, Iskander, George, Chan, Daniel S. H., Ho, Kitty K. K., Rice, Scott A., Black, David StC., Griffith, Renate, Kumar, Naresh
• Other Authors: Singapore Centre for Environmental Life Sciences and Engineering
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Biological sciences; Quorum Sensing; Biofilm Inhibition
• Online Access: https://hdl.handle.net/10356/144458
• Institution: Nanyang Technological University

Bacteria regulate their pathogenicity and biofilm formation through quorum sensing (QS), which is an intercellular communication system mediated by the binding of signaling molecules to QS receptors such as LasR. In this study, a range of dihydropyrrolone (DHP) analogues were synthesized via the lac...