Design and Synthesis of Lactams Derived from Mucochloric and Mucobromic Acids as Pseudomonas aeruginosa Quorum Sensing Inhibitors

• Main Authors: Almohaywi, Basmah, Taunk, Aditi, Nizalapur, Shashidhar, Iskander, George, Griffith, Renate, Kumar, Naresh, Wenholz, Daniel S., Biswas, Nripendra N., Ho, Kitty K. K., Rice, Scott A., Black, David StC.
• Other Authors: Singapore Centre for Environmental Life Sciences Engineering
• Format: Article
• Language: English
• Published: 2018
• Subjects: Quorum Sensing; Pseudomonas Aeruginosa
• Online Access: https://hdl.handle.net/10356/84293; http://hdl.handle.net/10220/45109
• Institution: Nanyang Technological University

Bacterial infections, particularly hospital-acquired infections caused by Pseudomonas aeruginosa, have become a global threat with a high mortality rate. Gram-negative bacteria including P. aeruginosa employ N-acyl homoserine lactones (AHLs) as chemical signals to regulate the expression of pathogen...