Dihydropyrrolones as bacterial quorum sensing inhibitors

• المؤلفون الرئيسيون: Almohaywi, Basmah, Yu, Tsz Tin, Iskander, George, Chan, Daniel S. H., Ho, Kitty K. K., Rice, Scott A., Black, David StC., Griffith, Renate, Kumar, Naresh
• مؤلفون آخرون: Singapore Centre for Environmental Life Sciences and Engineering
• التنسيق: مقال
• اللغة: English
• منشور في: 2020
• الموضوعات: Science::Biological sciences; Quorum Sensing; Biofilm Inhibition
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/144458
• المؤسسة: Nanyang Technological University

Bacteria regulate their pathogenicity and biofilm formation through quorum sensing (QS), which is an intercellular communication system mediated by the binding of signaling molecules to QS receptors such as LasR. In this study, a range of dihydropyrrolone (DHP) analogues were synthesized via the lac...