Dihydropyrrolones as bacterial quorum sensing inhibitors

• Main Authors: Almohaywi, Basmah, Yu, Tsz Tin, Iskander, George, Chan, Daniel S. H., Ho, Kitty K. K., Rice, Scott A., Black, David StC., Griffith, Renate, Kumar, Naresh
• 其他作者: Singapore Centre for Environmental Life Sciences and Engineering
• 格式: Article
• 語言: English
• 出版: 2020
• 主題: Science::Biological sciences; Quorum Sensing; Biofilm Inhibition
• 在線閱讀: https://hdl.handle.net/10356/144458

Bacteria regulate their pathogenicity and biofilm formation through quorum sensing (QS), which is an intercellular communication system mediated by the binding of signaling molecules to QS receptors such as LasR. In this study, a range of dihydropyrrolone (DHP) analogues were synthesized via the lac...