Structure and flexibility of non-structural proteins 3 and -5 of Dengue- and Zika viruses in solution

• Main Authors: Saw, Wuan Geok, Pan, Ankita, Manimekalai, Malathy Sony Subramanian, Grüber, Ardina, Grüber, Gerhard
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Biological sciences; Flavivirus; Dengue
• Online Access: https://hdl.handle.net/10356/144510
• Institution: Nanyang Technological University

Dengue- (DENV) and Zika viruses (ZIKV) rely on their non-structural protein 5 (NS5) including a methyl-transferase (MTase) and a RNA-dependent RNA polymerase (RdRp) for capping and synthesis of the viral RNA, and the non-structural protein 3 (NS3) with its protease and helicase domain for polyprotei...