Electrochemical and optical CMOS sensors design for biochemical detection

• المؤلف الرئيسي: Jiang, Yu
• مؤلفون آخرون: Zhang Qing
• التنسيق: Thesis-Doctor of Philosophy
• اللغة: English
• منشور في: Nanyang Technological University 2020
• الموضوعات: Engineering::Electrical and electronic engineering::Integrated circuits
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/144512
• المؤسسة: Nanyang Technological University

Population ageing has driven the incremental demands on portable and cost-efficient point-of-care diagnostics. However, most of the existing techniques require bulky and expensive high-end instruments. New methods based on CMOS sensors are possible solutions. In this thesis, three types of CMOS sensors are studied for biochemical detection: CMOS ion-sensitive field-effect transistor (ISFET) sensor for food safety screening, CMOS chronocoulometric sensor for the heavy metal monitor, and CMOS fluorescence sensor for near-infrared quantum dots detection. In-depth understanding of these novel CMOS sensors is presented here from working principles, circuit designs, to the experimental results. Sub-threshold amplifier and capacitive transimpedance amplifier (CTIA) are proposed to realize a high-sensitivity detection. Correlated double sampling (CDS) and pixel calibration are employed to reduce the variations in an array. The demonstrated CMOS biosensors are low-cost and miniaturized. They could become promising in personalized biomedical tests in future.