Electrochemical and optical CMOS sensors design for biochemical detection
Population ageing has driven the incremental demands on portable and cost-efficient point-of-care diagnostics. However, most of the existing techniques require bulky and expensive high-end instruments. New methods based on CMOS sensors are possible solutions. In this thesis, three types of CMOS...
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| Format: | Thesis-Doctor of Philosophy |
| Language: | English |
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Nanyang Technological University
2020
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| Online Access: | https://hdl.handle.net/10356/144512 |
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| Institution: | Nanyang Technological University |
| Language: | English |
| Summary: | Population ageing has driven the incremental demands on portable and cost-efficient point-of-care diagnostics. However, most of the existing techniques require bulky and expensive high-end instruments. New methods based on CMOS sensors are possible solutions.
In this thesis, three types of CMOS sensors are studied for biochemical detection: CMOS ion-sensitive field-effect transistor (ISFET) sensor for food safety screening, CMOS chronocoulometric sensor for the heavy metal monitor, and CMOS fluorescence sensor for near-infrared quantum dots detection. In-depth understanding of these novel CMOS sensors is presented here from working principles, circuit designs, to the experimental results. Sub-threshold amplifier and capacitive transimpedance amplifier (CTIA) are proposed to realize a high-sensitivity detection. Correlated double sampling (CDS) and pixel calibration are employed to reduce the variations in an array.
The demonstrated CMOS biosensors are low-cost and miniaturized. They could become promising in personalized biomedical tests in future. |
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