Effects of single nucleotide polymorphisms on the binding of afatinib to EGFR : a potential patient stratification factor revealed by modeling studies

• المؤلفون الرئيسيون: Kannan, Srinivasaraghavan, Tan, Daniel Shao-Weng, Verma, Chandra Shekhar
• مؤلفون آخرون: School of Biological Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2020
• الموضوعات: Science::Biological sciences; Free Energy; Peptides And Proteins
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/144576
• المؤسسة: Nanyang Technological University

The anticancer drug afatinib has been found to be more effective at inhibiting the oncogenic EGFR mutant exon 19 deletion (19del) over the oncogenic EGFR mutant L858R. The underlying mechanism has been hypothesized to result from differences in structural constraints introduced by the mutations and...