65 years of the double helix : the advancements of gene editing and potential application to hereditary cancer

• Main Authors: Tan, Zi Ying, Huang, Taosheng, Ngeow, Joanne
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Medicine; CRISPR-Cas; Gene Correction
• Online Access: https://hdl.handle.net/10356/144586
• Institution: Nanyang Technological University

Hereditary cancer predisposition syndromes are associated with germline mutations that lead to increased vulnerability for an individual to develop cancers. Such germline mutations in tumour suppressor genes, oncogenes and genes encoding for proteins essential in DNA repair pathways and cell cycle c...