Regulation of hepatokine gene expression in response to fasting and feeding : influence of PPAR-α and insulin-dependent signalling in hepatocytes

• Main Authors: Smati, S., Régnier, M., Fougeray, T., Polizzi, A., Fougerat, A., Lasserre, F., Lukowicz, C., Tramunt, B., Guillaume, M., Burnol, A.-F., Postic, C., Wahli, Walter, Montagner, A., Gourdy, P., Guillou, H.
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Medicine; Hepatokines; Insulin Receptor
• Online Access: https://hdl.handle.net/10356/144804
• Institution: Nanyang Technological University

Aim – In hepatocytes, the peroxisome proliferator-activated receptor (PPAR)-a and insulin receptor (IR) are critical for transcriptional responses to fasting and feeding, respectively. The present report analyzes the effects of nutritional status (fasting vs feeding) on the expression of a large p...